Statistische Verfahren in präklinischen Studien

Publikationen in Zeitschriften

Emmert M, Frömke C, Drach C, Heppe L, Kiss S, Patzelt C, Schindler A, Schöffski O, Stahmeyer J, Weber J, Sander U (2025): Variation in patient-reported outcomes after total hip replacement across ten high-volume hospitals in Germany: results from a multicenter, prospective, longitudinal Cohort Study. Eur J Health Econ DOI: 10.1007/s10198-025-01858-4

Zapf A, Frömke C, Hardt J, Rücker G, Voeltz D, Hoyer A (2024): Meta-analysis of diagnostic accuracy studies with multiple thresholds: Comparison of approaches in a simulation study. Biometrical Journal 66 (7), e202300101. DOI: 10.1002/bimj.202300101

Emmert M, Schindler A, Heppe L, Sander U, Patzelt C, Lauerer M, Nagel E, Frömke C, Schöffski O, Drach C (2024): Referring physicians‘ intention to use hospital report cards for hospital referral purposes in the presence or absence of patient-reported outcomes: a randomized trial. The European Journal of Health Economics. 25, 293-305. DOI: 10.1007/s10198-023-01587-6

Ortmann J, Heise JK, Janzen I, Jenniches F, Kemmling Y, Frömke C, Castell S (2023): Suitability and user acceptance of the eResearch system "Prospective Monitoring and Management App (PIA)"-The example of an epidemiological study on infectious diseases. PLoS One. 2023 Jan 3;18(1): e0279969. doi: 10.1371/journal.pone.0279969. PMID: 36595548; PMCID: PMC9810156.

Emmert M, Rohrbacher S, Meier F, Heppe L, Drach C, Schindler A, Sander U, Patzelt C, Frömke C, Schöffski O, Lauerer M (2023): The elicitation of patient and physician preferences for calculating consumer-based composite measures on hospital report cards: results of two discrete choice experiments. European Journal of Health Economics. Epub ahead of print. DOI: 10.1007/s10198-023-01650-2

Emmert M, Schindler A, Drach C, Sander U, Patzelt C, Stahmeyer J, Kühnel E, Lauerer M, Nagel E, Frömke C, Schöffski O, Heppe L (2022): The use intention of hospital report cards among patients in the presence or absence of patient-reported outcomes. Health Policy. 126(6), 541-548. DOI: 10.1016/j.healthpol.2022.03.015

Frömke C, Kirstein M, Zapf A (2021): A semiparametric approach for meta-analysis of diagnostic accuracy studies with multiple cut-offs. Research Synthesis Methods, 13(5), 612-621. DOI: 10.1002/jrsm.1579.

Zapf A, Albert C, Frömke C, Haase M, Hoyer A, Jones HE, Rücker G (2021): Meta-analysis of diagnostic accuracy studies with multiple thresholds: Comparison of different approaches. Biometrical Journal 63, 699-711. DOI: 10.1002/bimj.202000091.

Jung K, Vogel C, Zapf A, Frömke C (2019): Reproduzierbare Forschungsergebnisse: Anforderungen und Herausforderungen durch Data Science. mdi (2), S. 45–48.

Jensen, KC, Frömke C, Schneider B, Do Duc P, Gundling F, Birnstiel K et al. (2019): Case-control study on factors associated with a decreased milk yield and a depressed health status of dairy herds in northern Germany. BMC veterinary research 15 (1), S. 442. DOI: 10.1186/s12917-019-2190-4.

Pigeot I, Foraita R, Frömke C, Haller B, Hoffmann V, Zapf A (2019): Ethische Bewertung von Studien am Menschen außerhalb des regulatorischen Rahmens. Nicht bindend, aber von großer Wichtigkeit. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. DOI: 10.1007/s00103-019-02947-5.

Hüls A, Frömke C, Ickstadt K, Hille K, Hering J, von Münchhausen C, Hartmann M, Kreienbrock L (2017): Antibiotic Resistances in Livestock: A Comparative Approach to Identify an Appropriate Regression Model for Count Data. Front Vet Sci. May 31;4:71. doi: 10.3389/fvets.2017.00071. eCollection 2017.

Rios N, Adaskina N, Frömke C, Papendorf F, Schippert C, Koch A, Hillemanns P, Park-Simon TW (2016): The Benefit of Baseline Staging-Risk Assessment of Distant Breast Cancer Metastases by Tumor Stage. Anticancer Res. 36(9): 4909-14.

Hering J, Frömke C, von Münchhausen C, Hartmann M, Schneider B, Friese A, Rösler U, Kreienbrock L, Hille K (2016): Cefotaxime-resistent Escherichia coli in broiler farms – A cross-sectional investigation in Germany. Prev Vet Med. 125; 154-157.

Wonnemann M, Frömke C, Koch A (2015): Inflation of the Type I Error: Investigations on Regulatory Recommendations for Bioequivalence of Highly Variable Drugs. Pharm Res. 32(1): 135-143.

Campe A, Hoes C, Koesters S, Frömke C, Bessei W, Knierim U, Schrader L, Kreienbrock L, Thobe P (2015): Determinants of economic success in egg production in Germany – here: laying hens kept in aviaries or small-group housing systems. Landbauforsch Appl Agric Forestry Res 00(00): Online first 27.11.15, S. 1-12, DOI:10.3220/LBF1447678999000

Prüller S, Frömke C, Kaspar  H, Klein G, Kreienbrock L, Kehrenberg C (2015): Recommendation for a Standardised Method of Broth Microdilution Susceptibility Testing for Porcine Bordetella bronchiseptica. PLoS One. 10(4): e0123883.

Zeckey C, Wendt K, Mommsen P, Winkelmann M, Frömke C, Weidemann J, Stübig T, Krettek C, Hildebrand F (2015): Kinetic therapy in multiple trauma patients with severe blunt chest trauma: An analysis at a level-1 trauma center. Technol Health Care. 23(1): 63-73.

Eckelt E, Jarek M, Frömke C, Meens J, Goethe R (2014): Identification of a lineage specific zinc responsive genomic island in Mycobacterium avium ssp. paratuberculosis. BMC Genomics. 15 (1): 1076.

Ahlenstiel-Grunow, T, Koch A, Großhennig A, Frömke C, Sester M, Sester U, Schröder C,  Pape L (2014): A multicenter, randomized, open-labeled study to steer immunosuppressive and antiviral therapy by measurement of virus (CMV, ADV, HSV)-specific T cells in addition to determination of trough levels of immunosuppressants in pediatric kidney allograft recipients (IVIST01-trial): study protocol for a randomized controlled trial. Trials. 15: 324.

Schaumann F, Frömke C, Dijkstra D, Alessandrini F, Windt H, Karg E, Mueller M, Winkler C, Braun A, Koch A, Hohlfeld JM, Berendt H, Schmid O, Koch W, Schulz H, Krug N (2014): Effects of Ultrafine Particles on the Allergic Inflammation in the Lung of Asthmatics: Results of a double-blinded randomized Cross-over Clinical Pilot Study. Part Fibre Toxicol. 11(1): 39.

Hering J, Hille K, Frömke C, von Münchhausen C, Hartmann M, Schneider B, Friese A, Roesler U, Merle R, Kreienbrock L (2014): Prevalence and potential risk factors for the occurrence of cefotaxime resistant Escherichia coli in German fattening pig farms – A cross-sectional study. Prev Vet Med. 116 (1-2): 129-37.

Gross MM, Frömke C, Hecker H (2014): The timing of amniotomy, oxytocin and neuraxial analgesia and its association with labour duration and mode of birth. Arch Gynecol Obstet. 289(1): 41-8.

Giesemann AM, Raab P, Lyutenski S, Dettmer S, Bültmann E, Frömke C, Lenarz T, Lanfermann H, Goetz F (2014): Improved imaging of Cochlear nerve hypoplasia using a 3-tesla variable flip-angle turbo spin-echo sequence and a 7-cm surface coil. Laryngoscope. 124(3): 751-4.

Frömke C, Hothorn LA, Sczesny F, Onken J, Schneider M (2013): Analytical Method Transfer: Improving Interpretability with Ratio-Based Statistical Approaches. J Pharm Biomed Anal. 23 (74): 186-193.

Riesenberg A, Feßler AT, Frömke C, Kadlec K, Klarmann D, Kreienbrock L, Werckenthin C, Schwarz S (2013): Harmonization of antimicrobial susceptibility testing by broth microdilution for Rhodococcus equi of animal origin. J Antimicrob Chemother.  68(9): 2173-5.

Klingmann V, Spomer N, Lerch C, Stoltenberg I, Frömke C, Bosse HM, Breitkreutz J, Meissner T (2013): Favorable acceptance of mini-tablets compared with syrup: a randomized controlled trial in infants and preschool children. J Pediatr. 163(6): 1728-1732.

Mommsen P, Andruszkow H, Frömke C, Zeckey C, Wagner U, van Griensven M, Frink M, Krettek C, Hildebrand F (2013): Effects of accidental hypothermia on posttraumatic complications and outcome in multiple trauma patients. Injury. 44 (1): 86-90.

Schneider M, Frömke C, Mehnert E, Bärtsch P (2012): Evaluation der universitären sportmedizinischen Einrichtungen in Deutschland. Deut. Z. Sportmed. 63: 46-52.

Andruszkow H, Frink M, Frömke C, Matityahu A, Zeckey C, Mommsen P, Suntardjo S, Krettek C, Hildebrand F (2012): Tip apex distance, hip screw placement, and neck shaft angle as potential risk factors for cut-out failure of hip screws after surgical treatment of intertrochanteric fractures. Int Orthop. 36(11): 2347-54.

Mommsen P, Zeckey C, Andruszkow H, Weidemann J, Frömke C, Puljic P, van Griensven M, Frink M, Krettek C, Hildebrand F (2012): Comparison of Different Thoracic Trauma Scoring Systems in Regards to Prediction of Post-Traumatic Complications and Outcome in Blunt Chest Trauma. J. Surg. Res. 176(1): 239-47.

Petersen A, Ayerle GM, Frömke C, Hecker H, Gross MM, for the ProGeb Study Team (2011): The timing of interventions during labour: Descriptive results of a longitudinal study. Midwifery. 27 (6): e267-73.

Zeckey C, Tschernig T, Hildebrand F, Frink F, Frömke C, Dorsch M, Krettek C, Barkhausen T (2010): Macrophage activating lipopeptide-2 (MALP-2) exerts protective effects in a murine sepsis model. Shock. 33(6): 614-9.

Freudenberg LS, Jentzen W, Petrich T, Frömke C, Marlowe RJ, Heusner T, Brandau W, Knapp WH, Bokisch A (2010): Lesion dose in differentiated thyroid carcinoma metastases after rhTSH or thyroid hormone withdrawal: 124I PET/CT dosimetric comparisons. Eur. J. Nucl. Med. Mol. Imagin. 37(12): 2267-76.

Franzke T, Frömke C, Jähne J (2010): Postoperative hypoparathyroidism: risk factors and out-patient management following thyroid resections. Chirurg. 81(10): 909-14.

Petrich T, Korkmaz Z, Krull D, Frömke C, Meyer GJ, Knapp WH (2010): In vitro experimental (211) At-anti-CD33 antibody therapy of leukaemia cells overcomes cellular resistance seen in vivo against gemtuzumab ozogamicin. Eur. J. Nucl. Med. Mol. Imaging. 37(5): 851-61

Freundenberg LS, Frömke C, Petrich T, Marlowe RJ, Koska WW, Brandau W, Eising EG, Knust EJ, Bockisch A, Jentzen W (2010): Thyroid Remnant Dose: 124I-PET/CT Dosimetric Comparison of rhTSH versus Thyroid Hormone Withholding Before Radioiodine Remnant Ablation in Differentiated Thyoid Cancer. Exp. Clin. Endocrinol. Diabetes. 118(7): 393-9.

Rahe-Meyer N, Winterhalter M, Boden A, Froemke C, Piepenbrock S, Calatzis A, Solomon C (2009): Platelet concentrates transfusion in cardiac surgery and platelet function assessment by multiple electrode aggregometry. Acta Anaesthesiol Scand. 53: 168-175.

Gross MM, Burian RA, Frömke C, Hecker H, Schippert C, Hillemanns P (2009): Onset of labour: women's experiences and midwives' assessments in relation to first stage duration. Arch Gynecol Obstet. 280(6): 899-905.

Frömke C, Hothorn LA, Kropf S (2008): Nonparametric relevance-shifted multiple testing procedures for the analysis of high-dimensional multivariate data with small sample sizes. BMC Bioinformatics, 9, 54.

Ayerle GM, Hecker H, Frömke C, Hillemanns P, Groß MM (2008): Zusammenhänge zwischen Anwesenheit der Hebamme, Interventionen und dem Outcome der Geburt. Z Geburtsh Neonatol, 212: 176-182.

Mirzayan MJ, Gharabaghi A, Samii M, Frömke C, Tatagiba M, Krauss JK, Rosahl SK (2008): The diagnostic value of erythrocyte sedimentation rate in management of brain tumors. Neurol Res. 31(5): 514-7.

Athen K, Frömke C, Germonpré M (2005): Analysis of postcranial elements of cave bear material (Ursus spelaeus) from Goyet (Ardennes / Belgium). Bulletin de l'Institut Royal des Sciences Naturelles de Belgique, Brüssel, 75: 267-283.

Frömke C, Bretz F (2004): Simultaneous tests and confidence intervals for the evaluation of agricultural field trials, Agron J., 96(5): 1323-1330.

Athen K, Pfretzschner HU, Frömke C (2004): Modern Methods on Old Bones : Biostatistical Research on Fossil Ursids. Proceedings of the 9th International Cave Bear Symposium, Cahiers scientifiques, Lyon, 2: 75-80.

Buchveröffentlichungen

Zapf A, Frömke C, Rosenberger A (2017): „Doppelgänger lehren uns das Grundprinzip des statistischen Testens“ In: Vonthein R, Burkholder I., Muche R, Rauch G [Hrsg.]: Zeig mir mehr Biostatistik! Mehr Ideen und neues Material für einen guten Biometrie-Unterricht. Springer Spektrum, 61-70.

Poster, Weiterbildungen und Vorträge

Frömke C, Emmert M, Zapf A: Malen nach Zahlen in der Medizin: von Qualitätskontrolle bis Ergebniskommunikation. Kurt-Schwitters-Symposium der Hochschule Hannover, Fakultät III, Abteilung Design und Medien, 24./25.11.2022

Frömke C, Kirstein M, Zapf A: A nonparametric approach for meta-analysis of diagnostic accuracy studies with multiple cut-offs. DAGStat 2019 – 5th joint statistical meeting in München, 18.-22.03.2019

Haverkamp G, Lindemann M, Lühr J, Müller M, Roswora S, Ziesenis P, Hopf F, Patzelt C, Frömke C, Sander U: Warum Rehabilitanden onkologische Rehabilitationskliniken nicht weiterempfehlen. Eine Social Media Analyse. AGENS Methodenworkshop in Magdeburg, 27.-28.02.2019.

Sander U, Patzelt C, Kolb B, Frömke C, Emmert M: Warum Patienten ihr Krankenhaus nach einer Endoprothese der Hüfte nicht weiterempfehlen – Patientenberichte einer Krankenhausbewertungswebseite. 17. Deutscher Kongress für Versorgungsforschung (DKVF). Berlin, 10.-12.10.2018.

Frömke C, Zapf A: Nonparametric meta-analysis of diagnostic accurarcy studies with multiple cutoffs im Rahmen des Workshops „Dataset Challenge – Meta-Analysis of Diagnostic Accurarcy Studies with Multiple Cutoff-Values”. 63. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS) in Osnabrück, 02.-06.09.2018

Imhoff I, Amkenbrock L, Ciftci N, Granda Fernandez M, Pukowski A, Rolfes H, Patzelt C, Frömke C, Kolb B, Sander U: Welche Themen sprechen unzufriedene Rezensenten von Geburtskliniken an? Analyse von Erfahrungsberichten auf einem Klinikbewertungsportal. 25. GQMG-Jahrestagung in Berlin, 13.-14.04.2018. 

Frömke C, Kreienbrock L, Campe A, Bougeard S: Multiblockredundanzanalyse: wie viele Dimensionen sind angemessen für veterinär-epidemiologische Studien mit kleinen Fallzahlen? Vortrag, „Veterinärepidemiologie 3.0; Komplexe Probleme – einfache Antworten?; DACh Epidemiologietagung“, Berlin, 02.-04. September 2015.

Frömke C, Kreienbrock L, Campe C, Bougeard S: Multiblock redundancy analysis: Recommendations for the number of dimensions in veterinary epidemiological observational studies with small sample sizes, Vortrag, „61. Biometrisches Kolloquium der Deutschen Region der Internationalen Biometrischen Gesellschaft (IBS-DR)“, Dortmund, 15.-18. März 2015.

Frömke C, Kreienbrock L, Campe A, Bougeard S: Multiblock Redundancy Analysis: Performance in veterinary epidemiological observational studies with small sample sizes and correlated variables, Poster, „XXVII International Biometric Conference (IBC)“, Florenz, 05.-11. Juli 2014.

Frömke C, Hering J, Hille K, von Münchhausen C, Kreienbrock L: Hierarchien und Zähldaten: Erfahrungen mit unterschiedlichen Modellierungsstrategien in einer epidemiologischen Querschnittsstudie, Vortrag, „60. Biometrisches Kolloquium der Deutschen Region der Internationalen Biometrischen Gesellschaft (IBS-DR)“, Bremen, 10.-13. März 2014.

Frömke C, Hering J, Hille K, Kreienbrock L: Hierarchische Modellierung von Zähldaten: Erfahrungen am Beispiel der RESET-Querschnittsstudie, Vortrag, „Veterinärmedizinische Epidemiologie in Klinik und Bestandsmedizin; DACh Epidemiologietagung“, Hannover, 04.-09. September 2013.

Stryhn H, Kreienbrock L, Frömke C: Strategies for statistical modelling within hierarchical data structures, Workshop, „Veterinärmedizinische Epidemiologie in Klinik und Bestandsmedizin; DACh Epidemiologietagung“, Hannover, 04.-09. September 2013.

Frömke C, Schneider M, Hothorn LA: Analytical method transfer: proposals for the location-scale approach and tolerance intervals, Vortrag, „Non-Clinical Statistics Conference”, Lyon, 27.-29. September 2010.

Frömke C, Groß MM, Hecker H: Darstellung von zeitkonstanten und zeitabhängigen Interventionen auf den Geburtsverlauf in Übergangsmodellen, Poster, „51. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie“, Leipzig, 10.-14. September 2006.

Frömke C, Hothorn LA, Onken J, Sczesny F: Biostatistical aspects of transferring an analytical method to a second pharmaceutical laboratory, Vortrag, „Non-Clinical Statistics Conference”, Potsdam, 26.-28, September 2006.

Frömke C, Hecker H: Time-varying and time-constant factors in the analysis of childbirth, International Study Day, Vortrag, „Dynamics during Labour”, Hannover, 05. Juli 2006.

Frömke C, Kropf S, Bretz F, Hothorn LA: Stepwise tests for testing the ratio of two treatments in mircoarrays. 49. Biometrisches Kolloquium, Vortrag, Wuppertal, 18.-21.03.2003.

Schratz C: Interaktionskontraste im gemischten Modell. Internationaler Workshop „Example-based introduction to the analysis of mixed models“, Vortrag, Hannover, 24.-26.10.2001.

Koordination des Bachelorstudienganges Medizinisches Informationsmanagement